Document Type

Article

Publication Date

9-1-2012

Comments

This article is published in International Journal of Hypertension.

Volume 2012, 2012, Article number121740.

The published version is available at DOI: 10.1155/2012/121740. © 2012 Marcio Augusto Fressatto de Godoy et al.

Abstract

Ang-(1-7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1-7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles of Ang-(1-7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues. However, more studies are necessary to determine a relevant role for Ang-(1-7) in the gastrointestinal system. The Ang-(1-7) actions are mediated by a distinct, functional, Ang-(1-7) receptor: the Mas receptor as shown by diverse studies involving site-specific binding techniques, selective antagonists, and targeted gene deletion. This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1-7) in diverse systems.

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