Document Type
Article
Publication Date
5-15-2024
Abstract
Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most complex and difficult viral infections to cure. The difficulty in developing curative strategies arises in large part from the development of latent viral reservoirs (LVRs) within anatomical and cellular compartments of a host. The clustered regularly interspaced short palindromic repeats/ CRISPR-associated protein 9 (CRISPR/Cas9) system shows remarkable potential for the inactivation and/or elimination of integrated proviral DNA within host cells, however, delivery of the CRISPR/Cas9 system to infected cells is still a challenge. In this review, the main factors impacting delivery, the challenges for delivery to each of the LVRs, and the current successes for delivery to each reservoir will be discussed.
Recommended Citation
Gurrola, Theodore; Effah, Samuel; Sariyer, Ilker; Dampier, Will; Nonnemacher, Michael; and Wigdahl, Brian, "Delivering CRISPR to the HIV-1 Reservoirs" (2024). Kimmel Cancer Center Faculty Papers. Paper 129.
https://jdc.jefferson.edu/kimmelccfp/129
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
38812680
Language
English
Included in
Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Chemicals and Drugs Commons, Microbiology Commons, Viruses Commons
Comments
This article, first published by Frontiers Media, is the author's final published version in Frontiers in Microbiology, Volume 15, 2024, Article number 1393974.
The published version is available at https://doi.org/10.3389/fmicb.2024.1393974.
Copyright © 2024 Gurrola, Effah, Sariyer, Dampier, Nonnemacher and Wigdahl