Jefferson Journal of Psychiatry


Monoamine oxidase inhibitors (MAOIs) are now recognized as effective medications in the treatment of major depression (1). However, their clinical use has been limited by the risk of severe hypertensive reactions to oral tyramine challenge. Prevention of this so-called "cheese effect " requires adherence to diet restrictions that can lead to problems with patient compliance to MAOIs.

L-deprenyl is a selective MAO-B inhibitor that is reportedly free of the "cheese effect" (2). This review will discuss the clinical and theoretical importance of this interesting drug.

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