Jefferson Journal of Psychiatry


With this article we inaugurate our efforts to expand the scope of the Journal beyond the walls of Jefferson. We thus open the Journal to residents of all programsand invite them to share their clinical experience and research. Circulation will include contributing programs.


The differential diagnosis of psychosis associated with depression includes schizophrenia, schizoaffective and major affective disorders. Depression associated with schizophrenia may be a prominent feature of the patient's early presentation (I), or manifest itself only as the psychotic symptoms resolve (2, 3). Neuroleptics may play a causal role in the development of post-psychotic depression . This drug effect may be linked to genetic factors (4). In the following case , the patient presented in a floridly psychotic state after having castrated himself. Depression did not appear to be a prominent feature of hisinitial presentation. Only later in the course of his treatment did depressive symptoms manifest themselves.

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