Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm.

Authors

Christine J Kurian, Thomas Jefferson UniversityFollow
Colin Thomas, Thomas Jefferson UniversityFollow
Sarah Houtmann, Thomas Jefferson UniversityFollow
Thomas Klumpp, Thomas Jefferson UniversityFollow
Adam Finn Binder, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

1-1-2020

Comments

This is the final publised version of the article from Frontiers in Oncology, 2020, Volume 10, Article 1497

The published version can also be found at: https://doi.org/10.3389/fonc.2020.01497

Copyright Kurian, et. al.

Abstract

Plasma cell dyscrasias and myeloproliferative neoplasms (MPN) are hematologic malignancies arising from two distinct hematopoietic cell lineages. They rarely occur concomitantly. Here, we report a case of a patient with a recent diagnosis of a JAK2 V617F positive MPN who presented with a new diagnosis of plasma cell leukemia. The patient had presented to the hospital with a leukocytosis predominantly comprised of plasma cells, followed by work-up involving peripheral blood flow cytometry, FISH analysis, and bone-marrow biopsy. FISH analysis was suggestive of a common progenitor cell for these distinct hematologic malignancies. To our knowledge, this case represents the second reported instance of a concomitant JAK2 positive MPN with primary plasma cell leukemia.

Recommended Citation

Kurian, Christine J; Thomas, Colin; Houtmann, Sarah; Klumpp, Thomas; and Binder, Adam Finn, "Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm." (2020). Division of Internal Medicine Faculty Papers & Presentations. Paper 37.
https://jdc.jefferson.edu/internalfp/37

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

32974181

Language

English