Document Type
Article
Publication Date
9-1-2012
Abstract
Abstract Aims: Abnormal fetal and early postnatal growth is closely associated with adult-onset metabolic syndrome (MetS). However, the underlying etiological factors remain complex. The presence of the autoantibody against the angiotensin II type 1 receptor (AT1-Ab), a known risk factor for pre-eclampsia, may create a suboptimal intrauterine fetal environment. The current study investigated whether middle-aged offspring of AT1-Ab-positive mothers were prone to metabolic disorder development. Results: The AT1-Abs was detected in placental trophoblastic cells, capillary endothelium, and milk of pregnant rats actively immunized with the second extracellular loop of the AT1 receptor. AT1-Abs in newborn rats induced vasoconstriction, increased intracellular-free Ca(2+) in vitro, and was undetectable 7 weeks later. Immunized group offspring exhibited increased weight variability and insulin resistance at 40 weeks of age under a normal diet, evidenced by elevated fasting serum insulin and homeostasis model assessment score compared with the vehicle control. To further observe metabolic alterations, the offspring were given a high-sugar diet (containing 20% sucrose) 40-48 weeks postnatally. The fasting plasma glucose in immunized group offspring was markedly increased. Concomitantly, these offspring manifested increased visceral adipose tissue, increased fatty liver, increased triglycerides, decreased high-density lipoprotein cholesterol, and decreased adiponectin levels, indicative of MetS. Innovation: AT1-Abs could be transferred from mother to offspring via the placenta and milk. Moreover, offspring of an AT1-Ab-positive mother were more vulnerable to MetS development in middle age. Conclusion: AT1-Ab-positivity of mothers during pregnancy is a previously unrecognized "silent" risk factor for MetS development in their offspring. Antioxid. Redox Signal. 17, 733-743.
Recommended Citation
Zhang, Suli; Zhang, Xi; Yang, Lihong; Yan, Zi; Yan, Li; Tian, Jue; Li, Xiaoyu; Song, Li; Wang, Li; Yang, Xiaoli; Zheng, Ronghua; Lau, Wayne Bond; Ma, Xinliang; and Liu, Huirong, "Increased susceptibility to metabolic syndrome in adult offspring of Angiotensin type 1 receptor autoantibody-positive rats." (2012). Department of Emergency Medicine Faculty Papers. Paper 11.
https://jdc.jefferson.edu/emfp/11
PubMed ID
22304458
Included in
Alternative and Complementary Medicine Commons, Medical Pathology Commons, Medical Physiology Commons
Comments
This article is peer reviewed. The original version is published in Antioxidants and Redox Signaling, 2012 Sep 1;17(5):733-43. © Mary Ann Liebert, Inc.