Document Type
Article
Publication Date
9-1-2021
Abstract
Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by the onset of rash at a fixed location on the body each time a specific medication is ingested. With each recurrence, the eruption can involve additional sites. Lesions can have overlying vesicles and/or bullae, and when they cover a significant percentage of body surface area, the eruption is referred to as generalized bullous fixed drug eruption (GBFDE). Due to the widespread skin denudation that can be seen in this condition, GBFDE may be confused clinically with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). While treatments described for GBFDE include supportive care, topical and/or systemic steroids, and, recently, cyclosporine, the mainstay of management involves identifying and discontinuing the causative drug. This review article will provide an overview of FDE with an emphasis on its generalized bullous variant.
Recommended Citation
Anderson, Hannah J. and Lee, MD, Jason B., "A Review of Fixed Drug Eruption with a Special Focus on Generalized Bullous Fixed Drug Eruption." (2021). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 156.
https://jdc.jefferson.edu/dcbfp/156
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
34577848
Language
English
Comments
This article is the author's final published version in Medicina (Lithuania), Volume 57, Issue 9, September 2021, Article number 925.
The published version is available at https://doi.org/10.3390/medicina57090925
Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).