PD1 inhibitor induced inverse lichenoid eruption: a case series

Authors

Mansha Sethi, Thomas Jefferson UniversityFollow
Vaibhav Garg, Thomas Jefferson UniversityFollow
Jason Lee, Thomas Jefferson UniversityFollow
Sherry Yang, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

12-15-2020

Comments

This article is the author’s final published version in Dermatology online journal, Volume 26, Issue 12, December 2020, Article number 11.

The published version is available at https://escholarship.org/uc/item/66b8298z. Copyright © Sethi et al.

Abstract

The increased use of monoclonal antibodies that target the immune checkpoint T cell receptor programmed death-1 (PD1) to treat numerous solid tumors has led to several reports describing associated cutaneous adverse events. Although lichenoid reactions have been well described, we propose that PD1 inhibitor-induced inverse lichenoid eruption (PILE) is a distinct variant. We describe two patients who presented with nearly identical deeply erythematous, malodorous, eroded anogenital plaques with focal crusting. Diagnosis of PILE was established given the biopsy findings and temporal association with PD1 inhibitor therapy. Treatment with clobetasol ointment was successful without necessitating discontinuation of immunotherapy. The findings were consistent with the only other previously published case of inverse lichenoid eruption in the groin secondary to PD1 inhibitors.

Recommended Citation

Sethi, Mansha; Garg, Vaibhav; Lee, Jason; and Yang, Sherry, "PD1 inhibitor induced inverse lichenoid eruption: a case series" (2020). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 148.
https://jdc.jefferson.edu/dcbfp/148

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

33423421

Language

English