Inverse expression of fas ligand and asthma-related cytokines in an apergillus challenge murine model of asthma

Authors

T. Lin, MD, Thomas Jefferson University Hospital
Allyson Larkin, MD, Thomas Jefferson University Hospital
S. Sharma, MD, Thomas Jefferson University Hospital
S. Patel, MD, Thomas Jefferson University Hospital
J. Peterson, MD, Thomas Jefferson University Hospital
S. Kierstein, MD, University of Pennsylvania
A. Haczku, MD, University of Pennsylvania
J. Zangrilli MD, University of PennsylvaniaFollow

Abstract

Introduction

Resolution of inflammation in asthma is typically thought of as a passive phenomenon in which proinflammatory Th2-type cytokines wane after the initial trigger. We hypothesized that active mechanisms, including anti-inflammatory cytokines and proapoptotic factors, contribute to this process. Fas Ligand (FasL) expression was particularly interesting since important effector cells in asthma (e.g. eosinophils and T helper cells) are Fas-sensitive.

Recommended Citation

Lin, MD, T.; Larkin, MD, Allyson; Sharma, MD, S.; Patel, MD, S.; Peterson, MD, J.; Kierstein, MD, S.; Haczku, MD, A.; and Zangrilli MD, J. (2006) "Inverse expression of fas ligand and asthma-related cytokines in an apergillus challenge murine model of asthma," The Medicine Forum: Vol. 8, Article 4.
DOI: https://doi.org/10.29046/TMF.008.1.003
Available at: https://jdc.jefferson.edu/tmf/vol8/iss1/4