Gastric Nodules as a Rare Presentation of Diffuse Large B Cell Lymphoma

Authors

• Hamzah Shariff, MD, Thomas Jefferson University HospitalFollow
• Ghazal Ghafari, DO, MPH, Geisinger Medical Center, Danville, PA
• Anila Mahesh, MD, Geisinger Wyoming Valley Medical Center, Wilkes Barre, PA
• Kishore Kumar, MD, Geisinger Wyoming Valley Medical Center, Wilkes Barre, PA

Abstract

Diffuse large B-cell lymphoma (DLBCL) commonly involves the gastrointestinal tract, though typical endoscopic findings include ulcerations or masses. We report a 79-year-old woman with iron deficiency anemia found to have multiple small gastric nodules on endoscopy. Biopsy demonstrated DLBCL, with imaging confirming disseminated disease and secondary gastric involvement. This presentation is atypical, as nodular morphology is rarely described. Importantly, such findings may mimic other malignancies, particularly neuroendocrine tumors. This case highlights that gastric nodules may be an atypical manifestation of secondary DLBCL and underscores the necessity of adequate tissue biopsy to establish diagnosis and guide management.

Recommended Citation

Shariff, MD, Hamzah; Ghafari, DO, MPH, Ghazal; Mahesh, MD, Anila; and Kumar, MD, Kishore (2026) "Gastric Nodules as a Rare Presentation of Diffuse Large B Cell Lymphoma," The Medicine Forum: Vol. 27, Article 17.
Available at: https://jdc.jefferson.edu/tmf/vol27/iss1/17