Patent foramen ovale (PFO) is a congenital cardiac variant caused by failure of the closure of a passage in the atrial septum. It is quite common, occurring in as much as 27% of the population based on autopsy studies. Most cases of PFOs are incidentally discovered or found during work-up of cryptogenic strokes as a potential cause of the stroke.1 New research is being conducted on the role PFOs play in hypoxia from intracardiac right-to-left shunting, including in patients with co-existent cardiovascular and pulmonary disease
Janadhyala, MD, Jaya and Foster, MD, Jonathan
"A Case of Patent Foramen Ovale as a Cause of Persistent Hypoxia,"
The Medicine Forum: Vol. 23, Article 9.
Available at: https://jdc.jefferson.edu/tmf/vol23/iss1/9