Multiple myeloma is a plasma cell dyscrasia in which neoplastic plasma cells pathologically produce monoclonal immunoglobulin and infiltrate bone marrow throughout the skeletal system. The disease is classically characterized by bone pain caused by lytic bone lesions, marked increases in monoclonal antibodies in blood or urine, hypercalcemia, and other systemic signs and symptoms of malignancy including weight loss and night sweats. A rare variant of multiple myeloma presents with extramedullary plasmacytomas, or plasma cell tumors, which arise in organs outside of the bone marrow1. The case presented here exhibits this disease variant, with a woman with severe multiple myeloma refractory to multiple treatment modalities who was found to have a pancreatic plasmacytoma.
Robbins, MD, Justin and Habig, MD, Gregory
"Pancreatic Plasmacytoma: A Rare Extramedullary Manifestation of Multiple Myeloma,"
The Medicine Forum: Vol. 22, Article 18.
Available at: https://jdc.jefferson.edu/tmf/vol22/iss1/18