Capillary leak syndrome (CLS) is a rare clinical disease that causes edema, hypoproteinemia, episodic hypotension, dyspnea, hyponatremia, and weight gain that can be life threatening1. Although the underlying pathology is currently unknown, CLS is thought to be secondary to a systemic process associated with hyperpermeability of the body's microcirculation, resulting from a diffuse and severe disruption of the endothelium and causing generalized edema and often acute respiratory distress2.
Mehta, MD, Ankita and Shah, MD, Mansi
"Case Report: Uncontrolled Anasarca: Capillary Leak Syndrome,"
The Medicine Forum: Vol. 17
, Article 8.
Available at: https://jdc.jefferson.edu/tmf/vol17/iss1/8