Distal Renal Tubular Acidosis and Diabetes Insipidus Leading to the Diagnosis Of Sjögren's Syndrome

Authors

Loheetha Ragupathi, MD, Thomas Jefferson UniversityFollow
Elijah Grillo, MD, Thomas Jefferson UniversityFollow
Jonathan Yadlosky, MD, Thomas Jefferson UniversityFollow
Ravi Sunderkrishnan, MD, Thomas Jefferson UniversityFollow

Abstract

INTRODUCTION

Sjögren's syndrome is a chronic inflammatory disease characterized by the infiltration and progressive destruction of salivary and lacrimal glands. A common presentation involves the complaints of dry eyes and dry mouth, known as the “sicca complex.” Extra-glandular involvement is not uncommon, and is known to involve the lungs, vascular and peripheral nervous system, and kidney.1 The reported renal involvement ranges broadly from 2 – 67%,and is variably defined: the most commonly reported renal pathology is an a tubulo- interstitial nephritis resulting in tubular dysfunction and immune-mediated glomerular disease; however distal renal tubular acidosis (RTA) in particular can be present in 20-30% of cases.2,3 Although there have been case reports of patients with Sjögren's syndrome presenting with distal RTA during the course of the disease, to our knowledge, a diagnosis of Sjögren's syndrome made solely on the basis of renal manifestations without any overt physical findings of the disease has not been documented.

Recommended Citation

Ragupathi, MD, Loheetha; Grillo, MD, Elijah; Yadlosky, MD, Jonathan; and Sunderkrishnan, MD, Ravi (2016) "Distal Renal Tubular Acidosis and Diabetes Insipidus Leading to the Diagnosis Of Sjögren's Syndrome," The Medicine Forum: Vol. 17, Article 15.
DOI: https://doi.org/10.29046/TMF.017.1.016
Available at: https://jdc.jefferson.edu/tmf/vol17/iss1/15