Considering potential physiologic causes of volume overload in clinical practice, such as heart failure, renal failure, nephrotic syndrome, or portal hypertension, may yield insight into directing therapy beyond switching from oral to intravenous diuretic therapy. Appropriate oral therapies that achieve effective diuresis may reduce costs, address shortages of intravenous loop diuretics, reduce the need for unnecessary inpatient admissions by facilitating outpatient management, allow earlier optimization of outpatient regimens, and decrease the length of hospital stay.