Document Type
Article
Publication Date
8-1-2023
Abstract
BACKGROUND: There is increasing heterogeneity in the clinical phenotype of patients admitted to the intensive care unit (ICU) with coronavirus disease 2019 (COVID-19,) and reasons for mechanical ventilation are not limited to COVID pneumonia. We aimed to compare the characteristics and outcomes of intubated patients admitted to the ICU with the primary diagnosis of acute hypoxemic respiratory failure (AHRF) from COVID-19 pneumonia to those patients admitted for an alternative diagnosis.
METHODS: Retrospective cohort study of adults with confirmed SARS-CoV-2 infection admitted to nine ICUs between March 18, 2020, and April 30, 2021, at an urban university institution. We compared characteristics between the two groups using appropriate statistics. We performed logistic regression to identify risk factors for death in the mechanically ventilated COVID-19 population.
RESULTS: After exclusions, the final sample consisted of 319 patients with respiratory failure secondary to COVID pneumonia and 150 patients intubated for alternative diagnoses. The former group had higher ICU and hospital mortality rates (57.7% vs. 36.7%, P
CONCLUSIONS: Mechanically ventilated COVID-19 patients admitted to the ICU with COVID-19-associated respiratory failure are at higher risk of hospital death and have worse ICU utilization outcomes than those whose reason for admission is unrelated to COVID pneumonia.
Recommended Citation
Johnson, Jesse; Mallari, Kashka F.; Pepe, Vincent; Treacy, Taylor; McDonough, Gregory; Khaing, P.; McGrath, Christopher; George, Brandon; and Yoo, Erika J., "Mechanically Ventilated COVID-19 Patients Admitted to the Intensive Care Unit in the United States With or Without Respiratory Failure Secondary to COVID-19 Pneumonia: A Retrospective Comparison of Characteristics and Outcomes" (2023). Division of Pulmonary and Critical Care Medicine Faculty Papers. Paper 31.
https://jdc.jefferson.edu/pulmcritcarefp/31
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
37652859
Language
English
Comments
This article is the author's final published version in Acute and Critical Care, Volume 38, Issue 3, August 2023, Pages 298 - 307.
The published version is available at https://doi.org/10.4266/acc.2022.01123.
Copyright © 2023 The Korean Society of Critical Care Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.