Automated Assessment of Thoracic-Abdominal Asynchrony in Patients with Morquio Syndrome.

Authors

Madhavi V Ratnagiri, Department of Health Sciences, University of Delaware, Newark, DE 19716, USA
Yan Zhu, Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA
Tariq Rahman, Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA
Mary Theroux, Department of Anesthesiology and Perioperative Medicine & Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA
Shunji Tomatsu, Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA; Department of Pediatrics, Gifu University, Gifu 501-1193, Japan; Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USAFollow
Thomas H Shaffer, Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA; Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA; Center for Pediatric Lung Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA; Department of Physiology and Pediatrics, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA

Document Type

Article

Publication Date

5-15-2021

Comments

This article is the author's final published version in Diagnostics, Volume 11, Issue 5, May 2021, Article number 880.

The published version is available at https://doi.org/10.3390/diagnostics11050880.

Copyright © 2021 by the authors.

Abstract

Morquio syndrome is a rare disease caused by a disorder in the storage of mucopolysaccharides that affects multiple organs, including musculoskeletal, respiratory, cardiovascular, and digestive systems. Respiratory failure is one of the leading causes of mortality in Morquio patients; thus, respiratory function testing is vital to the management of the disease. An automated respiratory assessment methodology using the pneuRIP device and a machine-learning algorithm was developed. pneuRIP is a noninvasive approach that uses differences between thoracic and abdominal movements (thoracic-abdominal asynchrony) during respiration to assess respiratory status. The technique was evaluated on 17 patients with Morquio (9 females and 8 males) between the ages of 2 and 57 years. The results of the automated technique agreed with the clinical assessment in 16 out of the 17 patients. It was found that the inverse cumulative percentage representation of the time delay between the thorax and abdomen was the most critical variable for accurate evaluation. It was demonstrated that the technique could be successfully used on patients with Morquio who have difficulty breathing with 100% compliance. This technique is highly accurate, portable, noninvasive, and easy to administer, making it suitable for a variety of settings, such as outpatient clinics, at home, and emergency rooms.

Recommended Citation

Ratnagiri, Madhavi V; Zhu, Yan; Rahman, Tariq; Theroux, Mary; Tomatsu, Shunji; and Shaffer, Thomas H, "Automated Assessment of Thoracic-Abdominal Asynchrony in Patients with Morquio Syndrome." (2021). Department of Pediatrics Faculty Papers. Paper 102.
https://jdc.jefferson.edu/pedsfp/102

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

34063456

Language

English