MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128 expression levels were decreased in glioma, and identified p70S6K1 as a novel direct target of miR-128. Overexpression of miR-128 suppressed p70S6K1 and its downstream signaling molecules such as HIF-1 and VEGF expression, and attenuated cell proliferation, tumor growth and angiogenesis. Forced expression of p70S6K1 can partly rescue the inhibitory effect of miR-128 in the cells. Taken together, these findings will shed light to the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, and miR-128 may serve as a potential therapeutic target in glioma in the future.
Shi, Zhu-Mei; Wang, Jing; Yan, Zhiping; You, Yong-Ping; Li, Chong-Yong; Qian, Xu; Yin, Yu; Zhao, Peng; Wang, Ying-Ying; Wang, Xie-Feng; Li, Ming-Na; Liu, Ling-Zhi; Liu, Ning; and Jiang, Bing-Hua, "MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1." (2012). Kimmel Cancer Center Faculty Papers. Paper 21.
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