Methylphenidate and bupropion have been demonstrated as being effective adjuncts to serotonin reuptake inhibitors in the treatment of depression (1,2). The use of these medications in case of a depressed patient whose condition was resistant to several forms of monotherapy, monotherapy with "standard" augmentation and ECT. After only a partial response to fluoxetine and methylphenidate, bupropion was added, resulting in full, sustained remission.
Bobo, William M.D.
"Methylphenidate, Bupropion, and SSRI Triple Therapy,"
Jefferson Journal of Psychiatry: Vol. 16
, Article 8.
Available at: https://jdc.jefferson.edu/jeffjpsychiatry/vol16/iss1/8