Carbamazepine-Associated Hyponatremia

Authors

Mitchell S. Gandelman, MD, PhD, University of Connecticut
Sandra Dabora, MD, PhD, University of Connecticut
Rebecca L. Johnson, MD, University of Connecticut
Michelle B. Riba, MD, University of ConnecticutFollow

Abstract

Four cases of CBZ-induced or exacerbated hyponatremia are described in middle-aged to elderly females. Two cases are remarkable in that the pretreatment sodium levels demonstrate hyponatremia. A return to prior sodium levels was observed upon the discontinuation of carbamazepine therapy. No definitive conclusions can be drawn from these case reports; however, similarities in the cases can be examined as follows: (1) all four women have medical problems, in particular two patients had pre-existing hyponatremia; (2) all four patients were using concurrent medications; (3) all four women presented psychotic. A literature review examines risk factors, pharmacological mechanism, and the time course for CBZ-induced hyponatremia.

Recommended Citation

Gandelman, MD, PhD, Mitchell S.; Dabora, MD, PhD, Sandra; Johnson, MD, Rebecca L.; and Riba, MD, Michelle B. (1993) "Carbamazepine-Associated Hyponatremia," Jefferson Journal of Psychiatry: Vol. 11: Iss. 2, Article 8.
DOI: https://doi.org/10.29046/JJP.011.2.005
Available at: https://jdc.jefferson.edu/jeffjpsychiatry/vol11/iss2/8