Document Type
Article
Publication Date
6-1-2022
Abstract
BACKGROUND: Multiple studies have occurred to determine if a patient's blood type, Rhesus factor (Rh), and sociodemographic attributes contribute to contracting SARS-CoV-2. True association remains unknown.
METHODS: Inclusion criteria included in-patients who were tested for SARS-CoV-2 with blood type assessed. Study endpoints combined ABO, Rh and all-cause inpatient mortality (ACIM) with testing positivity. Pregnancy status was one of several secondary endpoints evaluated. A logistic regression analysis was used to estimate association.
RESULTS: Of the 27,662 patients who met inclusion criteria, Type A blood was associated with increased positivity [1.01 (1.0-1.21), P = .03]. Type B [1.10 (0.99-1.23), P = .08] and AB [0.98 (0.81-1.19), P = .84] showed no association. When evaluating ACIM, type A [1.18 (0.91-1.52), P = .22], B [1.13 (0.82- 1.56), P = .480], and AB [1.06 (0.62-1.81), P = .839] were not associated with increased mortality. The female subgroup was less likely to test positive [0.88 (0.82-0.986), P = .002]. Black patients demonstrated a higher likelihood of positivity when compared to White [1.96 (1.79-2.14), P < .001]. Non-pregnant women exhibited a 2.5 times greater likelihood of testing positive [2.49 (2.04-3.04), P < .001].
CONCLUSIONS: This study confirms results of previous research which showed SARS-Co-V-2 positivity related to blood type. It also confirms more recent research demonstrating inequities related to acquisition of SARS-CoV-2 for certain sociodemographic groups. Larger studies are warranted to confirm and further explore novel pregnancy findings.
Recommended Citation
Vacca, Maria L.; Vyas, Nikunj; Banks, Joshua; Joyce, Elaine; Hou, Cindy; Leiby, Benjamin E.; DeAngelo, Stefanie; Levin, Todd P.; Shingler-Nace, Autum; Mapp, Marilyn; Hiester, Ashlee; and Coughenour, Jonathan H., "Analysis of blood type for SARS-CoV-2 and correlation for disease acquisition in various sociodemographic groups including women of childbearing age." (2022). Division of Infectious Diseases and Environmental Medicine Faculty Papers. Paper 14.
https://jdc.jefferson.edu/didem/14
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Comments
This is the final published manuscript from the journal American Journal of Infection Control, 2022 Jun;50(6):598-601.
The article is also available on the journal's website: https:doi.org//10.1016/j.ajic.2022.03.012
Copyright. The Authors.