Document Type
Report
Publication Date
12-20-2022
Abstract
Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data extending these observations to 7 days of IIS wear. PWD (A1C ≤8.5%, C-peptide tmax (P < 0.001), Cmax (P < 0.05), and mean residence time (P < 0.0001). Area under the insulin concentration curve (AUC0–300) declined by ∼24% from days 0 to 7 (P < 0.05). These results confirm/extend previous observations showing progressive acceleration of insulin exposure over IIS wear time. This may have implications for PWD and designers of closed-loop algorithms, although larger studies are necessary to confirm this. The study was registered in clinicaltrials.gov (NCT04398030).
Recommended Citation
Kastner, Jasmin R.; Bailey, Timothy S.; Strange, Poul; Shi, Leon; Oberg, Keith A.; Strasma, Paul J.; Joseph, Jeffrey I.; and Muchmore, Douglas B., "Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear" (2022). Department of Anesthesiology Faculty Papers. Paper 86.
https://jdc.jefferson.edu/anfp/86
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Supp_FigS2.docx (111 kB)
Supp_FigS3.docx (99 kB)
Supp_FigS4.docx (86 kB)
Supp_FigS5.docx (176 kB)
Supp_TableS1.docx (18 kB)
PubMed ID
36342853
Language
English
Included in
Anesthesiology Commons, Endocrinology, Diabetes, and Metabolism Commons, Nutritional and Metabolic Diseases Commons
Comments
This article is the author's final published version in Diabetes Technology and Therapeutics, Volume 25, Issue 2, 2023, Pg. 143 - 147.
The published version is available at https://doi.org/10.1089/dia.2022.0323. Copyright © Jasmin R. Kastner, et al., 2023; Published by Mary Ann Liebert, Inc.