Resolution of inflammation in asthma is typically thought of as a passive phenomenon in which proinflammatory Th2-type cytokines wane after the initial trigger. We hypothesized that active mechanisms, including anti-inflammatory cytokines and proapoptotic factors, contribute to this process. Fas Ligand (FasL) expression was particularly interesting since important effector cells in asthma (e.g. eosinophils and T helper cells) are Fas-sensitive.
Lin, MD, T.; Larkin, MD, Allyson; Sharma, MD, S.; Patel, MD, S.; Peterson, MD, J.; Kierstein, MD, S.; Haczku, MD, A.; and Zangrilli MD, J.
"Inverse expression of fas ligand and asthma-related cytokines in an apergillus challenge murine model of asthma,"
The Medicine Forum:
Vol. 8, Article 4.
Available at: http://jdc.jefferson.edu/tmf/vol8/iss1/4