Kounis syndrome is an acute coronary syndrome occurring secondary to an anaphylactic reaction. A wide variety of triggers such as drugs and environmental exposures have been described for the so-called allergic myocardial infarction. The pathophysiology of Kounis syndrome is thought to be due to the release of inflammatory mediators such as histamine and cytokines by mast cells and eosinophils resulting in either coronary vasospasm, myocardial infarction or stent thrombosis.
Hullman, MS4, Jonathan; Kim, MD, Jaehee; and Marhefka, MD, FACC, FACP, Gregary D.
"Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome,"
The Medicine Forum: Vol. 17
, Article 4.
Available at: http://jdc.jefferson.edu/tmf/vol17/iss1/4