Document Type
Article
Publication Date
7-10-2024
Abstract
Langerhans cell histiocytosis (LCH) is a complex disorder characterized by the clonal proliferation of Langerhans cells, primarily affecting children and adolescents. This condition exhibits a wide spectrum of clinical presentations, necessitating a multidisciplinary approach for diagnosis, treatment, and follow-up. Cutaneous manifestations of LCH are significant, mimicking common dermatoses and posing diagnostic challenges. [18F]Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) has emerged as an important tool in the evaluation of pediatric LCH, offering insights into disease activity, extent, and therapeutic response. Moreover, FDG-PET provides a non-invasive means to distinguish between active LCH skin lesions and other dermatological conditions with similar clinical appearances, enhancing diagnostic accuracy and aiding in disease monitoring. This educational review summarizes the utility of nuclear imaging techniques, with a focus on PET scans, in the diagnosis and management of cutaneous pediatric LCH. A comprehensive literature search identified seven relevant articles, including retrospective studies and case reports. These studies highlight the efficacy of FDG-PET in localizing active LCH skin lesions, monitoring disease activity, and guiding treatment decisions. FDG-PET represents a valuable imaging modality for dermatologists, oncologists, and pediatricians managing pediatric LCH patients with cutaneous involvement. This non-invasive technique contributes to improved diagnostic accuracy and facilitates early intervention, ultimately enhancing patient care and outcomes.
Recommended Citation
Talasila, Sahithi; Teichner, Eric M.; Subtirelu, Robert C.; Talasila, Naga Chaitanya P.; Mannam, Sricharvi; Werner, Thomas; Alavi, Abass; and Revheim, Mona-Elisabeth, "Comprehensive Considerations for Dermatologists: The Application of FDG-PET in Evaluating Cutaneous Lesions in Pediatric Langerhans Cell Histiocytosis" (2024). Student Papers, Posters & Projects. Paper 141.
https://jdc.jefferson.edu/student_papers/141
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article, first published by Frontiers Media, is the author's final published version in Frontiers in Medicine, Volume 11, 2024, Article number 1378638.
The published version is available at https://doi.org/10.3389/fmed.2024.1378638.
Copyright © 2024 Talasila, Teichner, Subtirelu, Talasila, Mannam, Werner, Alavi and Revheim.