Document Type
Article
Publication Date
8-4-2026
Abstract
Spaceflight associated neuro-ocular syndrome (SANS) refers to the unique clinical and imaging characteristics that can develop during or following long-duration spaceflights. A number of theories about the pathogenesis of SANS have been proposed, while there is continuous interest and research about the effect of these missions on human health. The ocular translaminar pressure gradient, which is generated by the difference between intraocular pressure and retrolaminar intracranial pressure at the level of the lamina cribrosa, has been considered an important factor in the development of glaucoma and papilledema. The objective of this work is to review the changes in intraocular pressure and intracranial pressure in microgravity conditions and further discuss the role of translaminar pressure gradient in the pathogenesis of SANS.
Recommended Citation
Douglas, Vivian Paraskevi; Douglas, Konstantinos AA; Ong, Joshua; Waisberg, Ethan; Masalkhi, Mouayad; Paladugu, Phani; Berdahl, John; and Lee, Andrew G., "The Translaminar Pressure Gradient in Spaceflight Associated Neuro-ocular Syndrome: The Relationship between Intraocular and Intracranial Pressures and Its Role in Pathogenesis" (2026). SKMC Student Presentations and Publications. Paper 92.
https://jdc.jefferson.edu/skmcstudentworks/92
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in Space: Science and Technology (United States), Volume 6, 2026, Article Number 0578.
The published version is available at https://doi.org/10.34133/space.0578. Copyright © 2026 Vivian Paraskevi Douglas et al.