Document Type
Article
Publication Date
7-26-2026
Abstract
Extracellular matrix (ECM) dysregulation plays a significant role in the development of intervertebral disc disease (IVDD). The ECM around the chondrocytes in the nucleus pulposus (NP) is unique in that it contains ColVI. While linked to chondrocyte proliferation in cartilage, ColVI's specific role in IVD degeneration is less clear. Our aim was to determine the expression of ColVI in NP cells from degenerative IVDs, along with the effects of soluble ColVI on NP cells. Thus, we compared the expression levels of ColVI in human degenerated IVD samples, along with the effect of soluble ColVI on primary human NP cells. A higher Pfirrmann grade was associated with increased
Recommended Citation
Dalton, Jonathan; Divi, Srikanth N.; Eichbaum, Yasmine; Luksanapruksa, Panya; Ng, Mitchell K.; Huang, Rachel; Hilibrand, Alan S.; Vaccaro, Alex R.; Markova, Dessislava Z.; and Kepler, Christopher K., "The Biological Response of Human NP Cells to Soluble Collagen VI" (2026). Department of Orthopaedic Surgery Faculty Papers. Paper 276.
https://jdc.jefferson.edu/orthofp/276
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
42587749
Language
English
Comments
This article is the author’s final published version in Cells, Volume 15, Issue 15, 2026, Article number 1339.
The published version is available at https://doi.org/10.3390/cells15151339. Copyright © 2026 by the authors.