Document Type
Article
Publication Date
7-1-2026
Abstract
STUDY DESIGN/SETTING: Retrospective cohort study.
BACKGROUND: Signal changes within the spinal cord on magnetic resonance imaging (MRI) or myelomalacia, are frequently seen in patients with cervical myelopathy. While often assumed to predict the outcomes, their prognostic value remains uncertain. Therefore, this study aimed to: (1) describe the clinical characteristics of patients with myelomalacia undergoing Anterior cervical discectomy and fusion (ACDF); (2) evaluate whether MRI findings correlate with patient-reported outcomes (PROMs); and (3) determine whether morphology predict recovery.
METHODS: A retrospective review at a single tertiary care center was performed (2014-2021). Patients were included if they underwent a primary elective ACDF with an available preoperative MRI. PROMs were collected preoperatively and postoperatively. Sagittal MRI assessment included Yukawa T2 hyperintensity grade, T1 signal change, morphology subtype, canal diameter, and K-line. Axial MRI was used to assess cord compression. Spearman correlation assessed the relationships between MRI measurements and PROMs.
RESULTS: Sixty-two patients were included. Bright T2 hyperintensity was observed in 61%, T1 hypointensity in 75%, and fusiform morphology in 53%; 79% were K-line positive. No consistent correlations were identified between MRI severity and PROMs. Yukawa T2 grading, T1 hypointensity, and morphology demonstrated negligible associations with postoperative outcomes. Weak associations were seen between K-line positivity and both 12-month SF-12 MCS (r = 0.34) and change in 6-month VAS neck (r = -0.39), but these were not clinically significant.
CONCLUSION: Preoperative MRI severity and morphology of myelomalacia did not predict postoperative improvement after ACDF. These findings suggest that myelomalacia is best used as a diagnostic marker of spinal cord injury rather than a prognostic marker of recovery.
Recommended Citation
Ng, Mitchell K.; Mathew, Joshua; Oris, Robert J.; Lee, Yulia; Dalton, Jonathan; Baek, Gregorio; Thommana, Ashley; Green, William A.; Eichbaum, Yasmine; Hitchner, Morgan; Martinazzi, Brandon; Farooqi, Ali; Giakas, Alec; Gunter, Paul; Bijoor, Vinay; Vanchikorn, Andrew; Mangan, John J.; Kaye, David I.; Kurd, Mark F.; Cha, Thomas; Canseco, Jose A; Hilibrand, Alan S.; Vaccaro, Alexander R.; Kepler, Christopher K.; and Schroeder, Gregory D., "Myelomalacia Severity on Preoperative Magnetic Resonance Imaging Does Not Predict Patient-Reported Outcomes After Anterior Cervical Discectomy and Fusion" (2026). Department of Orthopaedic Surgery Faculty Papers. Paper 275.
https://jdc.jefferson.edu/orthofp/275
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
42643953
Language
English
Comments
This article is the author's final published version in Journal of Craniovertebral Junction and Spine, Volume 17, Issue 4, Pages 415-422.
The published version is available at https://doi.org/10.4103/jcvjs.jcvjs_106_26. Copyright © 2026 Journal of Craniovertebral Junction and Spine.