Document Type
Article
Publication Date
12-23-2023
Abstract
(1) Background: There are limited data available to guide clinical decision-making regarding the effects of hormone replacement therapy (HRT) in post-menopausal women with inflammatory bowel disease (IBD). In this study, we sought to characterize a population of post-menopausal women with IBD and to determine the effects of HRT on their disease activity. (2) Methods: A multicenter, retrospective, case–control cohort study of post-menopausal women with IBD was conducted. The physician global assessment (PGA) score was used to quantify disease activity. To control for the effects of menopause, IBD patients who had not undergone HRT were used as controls. (3) Results: There was a significant reduction in the frequency of PGA scores ≥2 post HRT treatment (p < 0.01). HRT treatment was associated with a 5.6× increase in the odds of post-HRT PGA score improvement compared to controls (OR 5.6; 95% CL 1.6, 19.7) in our univariate logistic regression analysis. (4) Conclusion: Post-menopausal IBD women who underwent HRT therapy showed an improvement in their disease symptoms following HRT compared to post-menopausal women without HRT therapy, who showed no change.
Recommended Citation
Freeman, Morgan; Lally, Lauren; Teigen, Levi; Graziano, Elliot; Shivashankar, Raina; and Shmidt, Eugenia, "Hormone Replacement Therapy Is Associated with Disease Activity Improvement among Post-Menopausal Women with Inflammatory Bowel Disease" (2023). Division of Gastroenterology and Hepatology Faculty Papers. Paper 97.
https://jdc.jefferson.edu/gastro_hepfp/97
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
38202098
Language
English
Comments
This article is the author's final published version in Journal of Clinical Medicine, Volume 13, Issue 1, 2023, Article number 88.
The published version is available at https://doi.org/10.3390/jcm13010088.
Copyright © 2023 by the authors