Drug Development and Promising Therapeutic Targets for Coronary Artery Disease: Current Landscape and Future Prospects: CVIA State-of-the-Art Review

Authors

• Shan Hu
• Zhen Guo
• Chenze Li
• Xiang Nie
• Jinjie Wang
• Jianmei He
• Cheng Zhuang
• Limin Zhang
• Depeng Li
• Yutong Lin
• Danan Wang
• Duanbin Li
• Fomin Zhang
• Qiongjun Zhu
• Xiaoyi Bao
• Ning Zhang
• Xiaolu Jiao
• Wenbin Zhang
• Beibei Du
• Hongmei Zhao
• Yongjian Zhu
• Bing Xiao
• Yupeng Liu
• Haoyu Wu
• Di Fan
• Peng Li
• Hongshan Chen
• Xin-Liang Ma, Thomas Jefferson UniversityFollow
• Jun Pu

Document Type

Article

Publication Date

9-25-2026

Comments

This article is the author’s final published version in Cardiovascular Innovations and Applications, Volume 11, Issue 1, 2026, Article number 39.

The published version is available at https://doi.org/10.15212/CVIA.2026.0011. Copyright © 2026 The Authors.

Abstract

Coronary artery disease (CAD) remains the leading cause of death globally, despite the limited efficacy of current pharmacological therapies. The need for safer and more effective treatment strategies has never been more urgent. This review provides a contemporary overview of advances in CAD drug development. Novel lipid-lowering agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) and angiopoietin-like protein 3 (ANGPTL3) inhibitors, anti-inflammatory therapies targeting interleukin pathways, and metabolic modulators have expanded the therapeutic landscape. Concurrently, precision medicine and drug repurposing approaches, informed by genomic profiling and biomarker-based stratification, are transforming the framework of CAD therapy. The integration of artificial intelligence into drug discovery further accelerates innovation. Herein, we summarize the current state of CAD pharmacotherapy, highlight recent translational and clinical breakthroughs, and discuss future directions aimed at addressing unmet needs and improving outcomes in this high-risk population.

Recommended Citation

Hu, Shan; Guo, Zhen; Li, Chenze; Nie, Xiang; Wang, Jinjie; He, Jianmei; Zhuang, Cheng; Zhang, Limin; Li, Depeng; Lin, Yutong; Wang, Danan; Li, Duanbin; Zhang, Fomin; Zhu, Qiongjun; Bao, Xiaoyi; Zhang, Ning; Jiao, Xiaolu; Zhang, Wenbin; Du, Beibei; Zhao, Hongmei; Zhu, Yongjian; Xiao, Bing; Liu, Yupeng; Wu, Haoyu; Fan, Di; Li, Peng; Chen, Hongshan; Ma, Xin-Liang; and Pu, Jun, "Drug Development and Promising Therapeutic Targets for Coronary Artery Disease: Current Landscape and Future Prospects: CVIA State-of-the-Art Review" (2026). Department of Emergency Medicine Faculty Papers. Paper 307.
https://jdc.jefferson.edu/emfp/307

Language

English