Intravitreal Dexamethasone Implants for Refractory Macular Edema in Eyes with Noninfectious Uveitis.
Document Type
Article
Publication Date
8-24-2021
Abstract
Macular edema (ME) is a common cause of visual loss among eyes with uveitis, and its management can be challenging. Steroids are an effective treatment for ME, and intravitreal dexamethasone (DEX) implants provide sustained steroid release. The purpose of this study is to evaluate intravitreal DEX implant on refractory ME in eyes with noninfectious uveitis. A retrospective study including 52 eyes of 37 patients with refractory uveitic ME was conducted from January 2011 through August 2017 at Linkou Chang Gung Memorial Hospital in Taiwan. Patients' demographic characteristics were collected. In addition, clinical information, including corrected visual acuity (VA), intraocular pressure (IOP), and central retinal thickness (CRT) on optical coherence tomography, was recorded and analyzed. During the study period, affected eyes received a total of 110 intravitreal DEX implants (range, one to six in each eye). After the first DEX implant injection in all eyes, VA significantly improved at one and two months. CRT significantly decreased one month after a single DEX implant, and the effect lasted for six months and waned over time. Patients receiving multiple DEX implants still showed significant decreases in CRT one month after the first implant. Increases in IOP were noted one month after the DEX implant, but the IOP could be medically controlled. Intravitreal DEX implants can effectively treat refractory uveitic ME, improving both VA and CRT with an acceptable safety profile. Further studies are necessary to evaluate the effect of multiple implants and long-term outcomes.
Recommended Citation
Kang, Eugene Yu-Chuan; Garg, Sunir; Chen, Hsi-Fu; Wu, Wei-Chi; Chen, Linda Yi-Hsing; Chou, Hung-Da; Liu, Laura; Chen, Kuan-Jen; and Hwang, Yih-Shiou, "Intravitreal Dexamethasone Implants for Refractory Macular Edema in Eyes with Noninfectious Uveitis." (2021). Wills Eye Hospital Papers. Paper 131.
https://jdc.jefferson.edu/willsfp/131
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
34501209
Language
English
Comments
This article is the author's final published version in Journal of Clinical Medicine, Volume 10, Issue 17, August 2021, Article number 3762
The published version is available at https://doi.org/10.3390/jcm10173762
Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).