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This article is the author's final published version in Journal of Ophthalmic and Vision Research, Volume 16, Issue 2, April 2021, Pages 158 - 164.

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Copyright © 2021 Karadag et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited.


Purpose: To compare anterior segment parameters in patients with Fuchs endothelial dystrophy (FED) who underwent Descemet stripping automated endothelial keratoplasty (DSAEK) in one eye and no corneal surgery in the fellow eye.

Methods: This prospective study was conducted on 28 eyes of 14 patients with FED who underwent DSAEK in one eye at least one year prior (DSAEK group) and no corneal surgery in the fellow eye (control group). Each eye was analyzed with the anterior segment optical coherence tomography, specular microscopy, and Scheimpflug imaging systems. Data were compared between the two groups.

Results: The mean age of the patients was 76.9±7.0 years. There were nostatistically significant differences in the mean central corneal thickness (CCT),central anterior chamber depth, anterior chamber angle parameters, cylinder andkeratometry values between two groups (allP-values>0.05). The paracentralcorneal thickness, corneal volume, endothelial cell density, and hexagonal cell ratiomeasurements were statistically significantly higher in the DSAEK group than thecontrol (allP-values < 0.05), and anterior chamber volume in the DSAEK groupwas significantly less than the control (P= 0.046). While posterior and total cornealdensitometry values in the DSAEK group were statistically significantly lower than thecontrol (P< 0.001 andP= 0.011, respectively), there were no statistically significantdifferences in the anterior or middle corneal densities (P= 0.108 andP= 0.134,respectively).

Conclusion: We found that total corneal densitometry value decreased in DSAEK group. Although DSAEK surgery did not affect the anterior chamber angle parameters, it reduced the anterior chamber volume and increased the corneal volume and paracentral corneal thickness due to the addition of the DSAEK graft.

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