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TRPM2 is a non-selective cation channel located in the plasma membrane of the cell. Upon activation, the channel opens, allowing calcium to enter into the cytosol of the cell, leading ultimately to the phosphorylation and activation of the enzyme Pyk2 (proline-rich tyrosine kinase 2). Once phosphorylated, Pyk2 translocates from the cytosol to the mitochondria, where it regulates the formation of the pore component of the mitochondrial calcium uniporter (MCU) complex. Consequently, this interaction is a key factor in mitochondrial calcium uptake and therefore mitochondrial bioenergetics.
Medicine and Health Sciences | Translational Medical Research
Baggett, Ariele; Fernandez-Sanz, Celia; De La Fuente, Sergio; Hoek, Johannes; and Sheu, Shey-Shing, "Pyk2 Expression and Localization in Cardiac Mitochondria and Its Role in Mitochondrial Calcium Regulation" (2019). Center for Translational Medicine Posters. 3.