The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the greatest obstacle in the current efforts to treat and cure HIV infection. Recent efforts to purge out latently infected memory CD4+ T-cells using latency-reversing agents have failed in clinical trials. This review discusses the epigenetic and non-epigenetic mechanisms of HIV latency control, major limitations of the current approaches of using latency-reversing agents to reactivate HIV latency in resting CD4+ T-cells, and potential solutions to these limitations.
Hokello, Joseph; Sharma, Adhikarimayum Lakhikumar; and Tyagi, Mudit, "Combinatorial use of both epigenetic and non-epigenetic mechanisms to efficiently reactivate hiv latency" (2021). Center for Translational Medicine Faculty Papers. Paper 82.
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