Eosinophilic granulomatosis with polyangiitis (eGPA) is a small- and medium-sized-vessel vasculitis with multi-organ manifestations. Given the rarity of eGPA, patients are often misdiagnosed for decades and may initially present with life-threatening manifestations of late-stage disease. Therefore, it is important to raise awareness of this condition and its associated signs and symptoms. This case report serves to describe a classic presentation of a patient with eGPA, as well as to delineate the diagnostic workup, acute management, and early outpatient follow-up required.
Given the life-threatening complications of this rare condition, it is important to raise awareness about eGPA. This is a classic presentation of eGPA in a patient with a decades-long asthma history, eosinophilia, new lung and gastrointestinal manifestations, and systemic symptoms. His serologies were significant for positive C-ANCA of anti-PR-3 specificity. His clinical course included screening for gastrointestinal, renal, and cardiac involvement as well as initiating steroid therapy, plasmapheresis, and rituximab.
Modi, MD, Anita and Ackermann, MD, Lily
"A Case of Eosinophilic Granulomatosis with Polyangiitis,"
The Medicine Forum: Vol. 19
, Article 20.
Available at: https://jdc.jefferson.edu/tmf/vol19/iss1/20