1. Human HCC cells have higher expression levels of IGF-1R, IRS1, and c-Met.
2. IRS1 interacts with c-Met. The role of IGF-1R in human HCC should be revisited.
3. Lentivirus-mediated shRNA delivery system targeting IGF-1R showed significant suppressive effects on HCC cell growth, promising a potential therapeutic treatment for human HCC.
Recommended CitationWei, PhD, Zhengyu; DeAngelis, M.S., Tiziana; Hurtt, B.S., Reginald; Baserga, M.D., Renato; and Doria, M.D., Ph.D, Cataldo, "The Type 1 Insulin-like Growth Factor Receptor in Hepatocellular Carcinoma Cell Lines" (2010). Department of Surgery Faculty Papers. Paper 30.