AIM: Can gene expression profiling be used to identify patients with T1-T2 melanoma at low risk for sentinel lymph node (SLN) positivity?
PATIENTS & METHODS: Bioinformatics modeling determined a population in which a 31-gene expression profile test predicted <5% SLN positivity. Multicenter, prospectively-tested (n = 1421) and retrospective (n = 690) cohorts were used for validation and outcomes, respectively.
RESULTS: Patients 55-64 years and ≥65 years with a class 1A (low-risk) profile had SLN positivity rates of 4.9% and 1.6%. Class 2B (high-risk) patients had SLN positivity rates of 30.8% and 11.9%. Melanoma-specific survival was 99.3% for patients ≥55 years with class 1A, T1-T2 tumors and 55.0% for class 2B, SLN-positive, T1-T2 tumors.
CONCLUSION: The 31-gene expression profile test identifies patients who could potentially avoid SLN biopsy.
Recommended CitationVetto, John T.; Hsueh, Eddy C.; Gastman, Brian R.; Dillon, Larry D.; Monzon, Federico A.; Cook, Robert W.; Keller, Jennifer; Huang, Xin; Fleming, Andrew; Hewgley, Preston; Gerami, Pedram; Leachman, Sancy; Wayne, Jeffrey D.; Berger, Adam C.; and Fleming, Martin D., "Guidance of sentinel lymph node biopsy decisions in patients with T1-T2 melanoma using gene expression profiling." (2019). Department of Surgery Faculty Papers. Paper 170.
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