Document Type
Article
Publication Date
3-3-2025
Abstract
PURPOSE: The purpose of this study was to assess the comparability of mean sensitivity (MS) values obtained using the Macular Integrity Assessment (MAIA; CenterVue S.p.A. [iCare], Padova, Italy) and Microperimeter-3 (MP-3; NIDEK CO., Ltd., Gamagori, Japan) microperimetry (MP) devices.
METHODS: This cross-sectional study includes subjects with healthy eyes, eyes with diabetes mellitus without diabetic retinopathy (DM no DR), diabetic retinopathy (DR), and non-exudative age-related macular degeneration (AMD). Patients underwent testing on both MAIA and MP-3 MP devices, using a 10-2 macular grid with 68 stimuli and identical parameters. A diagnosis-adjusted linear regression model and mixed modeling mapped MP-3 MS to MAIA MS and Bland-Altman analysis were used to assess the agreement.
RESULTS: One hundred eleven eyes (43 healthy eyes, 14 eyes with DM no DR, 32 eyes with DR, and 22 eyes with AMD) from 80 subjects (age = 57.2 ± 20.3 years) were enrolled. MAIA consistently showed higher MS than MP-3. The MP-3 device detected absolute scotomatous points in more eyes than MAIA (6 eyes [MAIA] vs. 10 eyes [MP-3]). Healthy eyes exhibited stronger agreements than those with DR (P < 0.001) or AMD (P = 0.015). Converting MP-3 to MAIA MS improved agreement and reduced coefficients of repeatability (CoRs) but did not fully account for inter-device variability. MP-3 classified more eyes as having relatively unstable or unstable fixation than MAIA (P = 0.014).
CONCLUSIONS: Both devices effectively detect retinal functional changes and scotomas. The conversion methods developed in this study can aid cross-device comparisons, but retinal pathologies (DM and AMD) introduce additional inter-device variability. Future studies incorporating multiple devices should account for this variability in their study design.
Recommended Citation
Marmalidou, Anna; Siddiqui, Haleema; Jamil, Muhammad Usman; Woo, Kwang Min; Yaghy, Antonio; Alibhai, A. Yasin; Takahashi, Hiroyuki; Kaiser, Stephanie; Effert, Keith; Zhao, Peter; Desai, Shilpa; Robinson, Christopher; Duker, Jay; and Waheed, Nadia, "Comparison Between MAIA and MP-3 In Healthy Subjects and Patients With Diabetes, Diabetic Retinopathy, and Age-Related Macular Degeneration" (2025). SKMC Student Presentations and Publications. Paper 56.
https://jdc.jefferson.edu/skmcstudentworks/56
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Included in
Diagnosis Commons, Endocrine System Diseases Commons, Equipment and Supplies Commons, Eye Diseases Commons
Comments
This article is the author's final published version in Investigative ophthalmology & visual science, Volume 66, Issue 3, March 2025, Article number 59.
The published version is available at https://doi.org/10.1167/iovs.66.3.59.
Copyright © 2025 The Authors