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Patent foramen ovale (PFO) is a common cardiac abnormality present in roughly 25% of the adult population. Although typically benign, patients with a PFO account for 50% of the population of cryptogenic stroke, an ischemic stroke with an unknown cause. Guidelines suggest closure in patients with a cryptogenic stroke found to have a PFO; however, it is unclear whether medical treatment should be given to all patients, regardless of PFO closure, and data is limited on the treatment outcomes. This retrospective chart analysis of 80 patients with a cryptogenic stroke found to have a PFO will investigate the criteria a multidisciplinary team used to determine whether patients should undergo PFO closure, receive medical therapy, or receive both. Additionally, it will investigate stroke recurrence, the percentage of patients with postprocedural complications, and the percentage of patients where the cause of the stroke was determined later. There is currently limited data on treatment outcomes and stroke recurrence in this cohort of patients, so this study will provide valuable knowledge that will help clinicians make more informed decisions on how to treat patients with cryptogenic stroke found to have a PFO.