Introduction: Celiac Disease (CD) is an autoimmune disease that manifests as inflammation in the small intestine that can be measured by both serology (tTG-IgA) and pathology (Marsh scores). Despite having two clear etiologies defining the disease, the relationship between these markers and the clinical presentation is unclear but the age at presentation has thought to be correlated with a worsened pathology.
Methods: This was a retrospective chart review at Thomas Jefferson University Hospital (TJUH). The study consisted of patients diagnosed with Celiac Disease at TJUH with both a Marsh score and a tTG-IgA antibody result. Analysis via correlation statistics looked at the relationship between age at diagnosis, body-mass index (BMI), presenting symptoms/complications, adherence to diet, and appropriate clinical values.
Results: There was no correlation between serological and pathological markers. There was no correlation between presenting age and Marsh score. Patients who fit the clear-cut definition for Celiac Disease presented with a wide variety of symptoms. The three major presenting symptoms were abdominal pain, bloating, and diarrhea.
Discussion: This study confirmed the nonspecific findings associated with the clinical presentation of Celiac Disease. Further investigation is warranted to determine the efficacy of implementing a screening protocol for Celiac Disease.
Recommended CitationDiMarino, Michael J.; Cohen, MD, Sidney; Moleski, MD, Stephanie; Cao, MD, Christopher; DiMarino, MD, Michael C.; and DiMarino, MD, Anthony, "Celiac Disease: Clinical-Pathological Correlation in 100 Consecutive Patients" (2021). Phase 1. Paper 37.