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It is critical to identify factors that contribute to disease severity among patients diagnosed with COVID-19. A systematic review of sex specific COVID-19 clinical outcomes demonstrated that female patients have lower rates of severe infection and mortality. This study investigates the correlation between biological sex and predisposing conditions as well as COVID-19 disease severity among 689 patients hospitalized within the St. Luke’s Hospital Network in Eastern PA/Western NJ. The sample is comprised of 45.8% female participants, of whom 30.2% identify as Hispanic or Latino, and 57.9% identidied their race as caucasian. Mean age of participants is 64.0 years (+/- 16.7). Data was extracted from patients electronic medical records both during their admission and after discharge. Chi squared test of independence was performed to examine the relation between known COVID-19 risk factors and COVID-19 infected female patients (n=314) compared to male patients (n=373). Risk factors strati􀉤ed by biological sex showed that female patients were more likely to have COPD (p < 0.05) and asthma (p < 0.001), and less likely to have smoke exposure (p < 0.05). There was no statistically significant difference in disease severity between the sexes with respect to intubation rate (p = 0.07) and mortality (p = 0.59). The results of this study are important to show that the trend of increased severity among males is not ubiquitous. Limitations of this study include small sample size, ongoing treatment protocol modifications with provider treatment bias, and overrepresentation of obesity.

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Comparison of Sex Specific Data among Hospitalized Covid-19 Patients