Thomas Jefferson University Research Magazine



Uveal melanoma is the most common eye cancer in adults. It metastasizes to the liver in 50 percent of patients, and there are no effective therapies to treat those metastases. Yet.

Jeffrey L. Benovic, PhD, Thomas Eakins Endowed Professor of Biochemistry and Molecular Biology, is globally recognized for research uncovering the mechanisms of G protein-coupled receptor (GPCR) signaling and how GPCR dysregulation contributes to disease. GPCRs regulate a variety of biological functions—from neurotransmission and sensory perception to the movement of cells in response to chemical stimuli. They have also been implicated in diseases ranging from cancer to neurological disorders.