Thomas Jefferson University Research Magazine



The interdisciplinary experts of Jefferson's Computational Medicine Center combine high-performance computing, data-driven hypothesis generation and wet laboratory work to unravel the biology and role of short RNA molecules with powerful regulatory roles. The Center’s research is led by Isidore Rigoutsos, PhD, Richard H. Hevner Professor of Computational Medicine; Yohei Kirino, associate professor of biochemistry and molecular biology; and Eric Londin, PhD, assistant professor of pathology, anatomy and cell biology.

The group has uncovered new RNA categories and many previously unsuspected molecules that act as regulators. They have also demonstrated that the identity and abundance of these newly discovered regulators depend on a person’s sex, population origin and ethnicity—as well as on tissue type, tissue state and disease.