Download Full Text (3.9 MB)
- Radiation-induced pulmonary fibrosis (RIPF) is a frequent outcome of thoracic radiation therapy, constraining safe tumor radiation dosage. Various animal models, such as mice, rats, and pigs, have been devised to study RIPF
- Current methods for inducing lung fibrosis in mice involve whole lung irradiation with doses between 2-20 Gy. These methods used fixed anterior and posterior (AP/PA) x-ray beams at 0º and 180º with analysis typically commencing 24 to 52 weeks post-radiation
- Current methods are unrepresentative of modern radiation therapy techniques and are limited by the associated long latency of RIPF
accelerated lung toxicity, radiation
Medicine and Health Sciences | Oncology | Radiation Medicine
Gerry, Andrew; Kunta, Charita; Francois, Noelle; DeAngelis, Tiziana; Shastri, Anuradha; Simone, Nicole; and Taleei, Reza, "Inducing Accelerated Lung Toxicity in Mice Using a Partial Arc SBRT Technique" (2023). Department of Radiation Oncology Posters. 1.