Uncovering novel growth modulators for non-small cell lung cancer (NSCLC) may lead to new therapies for these patients. Previous studies suggest Nit1 suppresses chemically induced carcinogenesis of the foregut in a mouse model. In this study we aimed to determine the role of Nit1 in a transgenic mouse lung cancer model driven by a G12D Kras mutation. Nit1 knockout mice (Nit1-/-) were crossed with KrasG12D/+ mice to investigate whether a G12D Kras mutation and Nit1 inactivation interact to promote or inhibit the development of NSCLC. We found that lung tumorigenesis was suppressed in the Nit1-null background (Nit1-/-:KrasG12D/+). Micro-CT scans and gross tumor measurements demonstrated a 5-fold reduction in total tumor volumes compared to Nit1+/+KrasG12D/+ (p
Recommended CitationWang, Yong Antican; Sun, Yunguang; Le Blanc, Justin M; Solomides, MD, Charalambos C.; Zhan, Tingting; and Lu, MD, Bo, "Nitrilase 1 modulates lung tumor progression in vitro and in vivo." (2016). Department of Radiation Oncology Faculty Papers. Paper 71.
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