Document Type

Article

Publication Date

1-1-2025

Comments

This article is the author's final published version in Journal of Neuroimaging, Volume 35, Issue 1, January/February 2025, Article number e70019.

The published version is available at https://doi.org/10.1111/jon.70019.

Copyright © 2025 The Author(s)

Abstract

BACKGROUND AND PURPOSE: This study presents automated atlas-based magnetization transfer (MT) measurements of the typically developing pediatric cervical spinal cord (SC). We report normative MT ratio (MTR) values from the whole cervical cord white matter (WM) and WM tracts, examining variations with age, sex, height, and weight.

METHODS: MT scans of 33 healthy females (mean age = 12.8) and 22 males (mean age = 13.09) were acquired from the cervical SC (C2-C7) using a 3.0 T MRI. Data were processed using the SC Toolbox, segmented, and registered to the PAM50 template. Affine and non-rigid transformations co-registered the PAM50 WM atlas to subject-specific space. MTRs were measured for the specific WM tracts (left and right dorsal fasciculus gracilis, dorsal fasciculus cuneatus, and lateral corticospinal tracts [LCST]) and the whole WM. Descriptive statistics, correlation analysis, and unpaired t-tests (p < 0.05) assessed relationships with age, height, weight, and sex.

RESULTS: Normative MTR measurements were obtained from all regions. The coefficients of variation were low to moderate. No significant differences (p > 0.05) were found across all the cervical levels. However, significant sex differences were observed in whole WM (p = 0.04) and LCST (p = 0.03). MTR values correlated positively with age, with significant correlations at C5 (r = 0.3, p false discovery rate = 0.04). A decreasing trend in MTR values across levels was found for whole WM (r = -0.2, p < 0.001).

CONCLUSIONS: This study provides an understanding of MTR values in pediatric cervical SC and their variations by sex, age, height, and weight, providing a baseline for comparisons in pediatric SC diseases.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

39923194

Language

English

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