Document Type

Article

Publication Date

12-1-2022

Comments

This article is the author's final published version in Journal of Nuclear Medicine : official publication, Society of Nuclear Medicine, Volume 63, Issue 12, December 2022, Pages 1887 - 1890.

The published version is available at https://doi.org/10.2967/jnumed.122.263902.

Copyright © 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Abstract

To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of 18F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%-88%) for the 2 central readers and above 90% (95% CI, 90%-95%) for SUVmax for central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The κ coefficients between the 2 expert readers and between central reads and site reads varied between 0.53 and 0.78. Conclusion: The NPV of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment and above 90% for SUVmax cut points of 1.8 and 3.5 with moderate to substantial agreements.

PubMed ID

35552246

Language

English

Available for download on Thursday, June 01, 2023

Included in

Radiology Commons

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