- Hepatitis C infection is the most common indication for liver transplantation in the US
- HCV infection of the liver allograft occurs within hours from circulating virions.
-Serum RNA levels are observed in the first several weeks.
-Acute hepatitis occurs in 2-6 months
-Chronic hepatitis occurs in 3-9 months
***Persistence of HCV infection is the rule after transplantation due to immune suppression
Chronic recurrent HCV infection post transplantation
- There are four distinct patterns of recurrent chronic HCV in the liver allograft.
-Usual chronic HCV (>70%)
-Fibrosing Cholestatic Hepatitis C (5-10%)
-Plasma cell-rich HCV
-HCV overlapping with rejection or autoimmune hepatitis
Recommended CitationHatem, Layla and Jiang, MD, PhD, Wei, "Fibrosing Cholestatic Hepatitis C Post-Liver Transplantation: A Case Study" (2014). Department of Pathology Honors Program Student Research Symposium. Poster 33.