CD44-targeted, indocyanine green-paclitaxel-loaded human serum albumin nanoparticles for potential image-guided drug delivery.
The use of multifunctional nanomedicines for image-guided drug delivery is currently being universally evaluated as a means of efficiently managing cancers and other diseases. In this study we evaluated the potential of an indocyanine green (ICG) and paclitaxel (PTX) loaded human serum albumin (HSA) nanoparticles that was conjugated with hyaluronic acid for use in image-guided drug delivery targeted to CD44-positive non-small cell lung cancer (NSCLC). Series of NSCLC cell lines were evaluated for the expression of CD44 using both western blot analysis and qRT-PCR and compared to a normal lung fibroblast cell line (MRC-5). Using Fluorescence microscopy and photoacoustic imaging (PA), we explored the ability of these targeted nanoparticles to selectively accumulate in NSCLC cell lines in comparison to MRC-5 and their potential for biomedical imaging towards their use for theranostic application. Results obtained suggest that these targeted nanoparticles have potential for application in both imaging and treatment of NSCLC.
Thangavel, Karthik; Lakshmikuttyamma, Asha; Thangavel, Chellappagounder; and Shoyele, Sunday A., "CD44-targeted, indocyanine green-paclitaxel-loaded human serum albumin nanoparticles for potential image-guided drug delivery." (2021). College of Pharmacy Faculty Papers. Paper 47.
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Available for download on Sunday, October 22, 2023
This article is the authors' final version prior to publication in Colloids and Surfaces B: Biointerfaces, Volume 209, October 2021, Article number 112162.
The published version is available at https://doi.org/10.1016/j.colsurfb.2021.112162. Copyright © Thangavel et al.