Mechanisms of modulation of brain microvascular endothelial cells function by thrombin.

Authors

Eugen Brailoiu, Temple University School of MedicineFollow
Megan M. Shipsky, Thomas Jefferson UniversityFollow
Guang Yan, Thomas Jefferson UniversityFollow
Mary E. Abood, Temple University School of Medicine
G. Cristina Brailoiu, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

2-15-2017

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Brain Research, Volume 1657, February 2017, Pages 167-175

The published version is available at https://doi.org/10.1016/j.brainres.2016.12.011 Copyright © Elsevier

Abstract

Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis. Blood-derived proteases such as thrombin may enter the brain during pathological conditions like trauma, stroke, and inflammation and further disrupts the permeability of the blood-brain barrier, via incompletely characterized mechanisms. We examined the underlying mechanisms evoked by thrombin in rat brain microvascular endothelial cells (RBMVEC). Our results indicate that thrombin, acting on protease-activated receptor 1 (PAR1) increases cytosolic Ca

Recommended Citation

Brailoiu, Eugen; Shipsky, Megan M.; Yan, Guang; Abood, Mary E.; and Brailoiu, G. Cristina, "Mechanisms of modulation of brain microvascular endothelial cells function by thrombin." (2017). College of Pharmacy Faculty Papers. Paper 33.
https://jdc.jefferson.edu/pharmacyfp/33

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

27998795

Language

English